Discordant Tissue-Specific Expression of SAPK/MAPK
نویسنده
چکیده
Background: Pursuant to establishing the proteomic distribution of MAPK ERK /MAPK p38 in the brain in a model of hypoxia-tolerance [Haddad, Protein Pept Lett, In press, 2007], I therein exclusively report the differential expression of MAPK JNK and related upstream and downstream kinases in various organs of the anoxia-tolerant turtle. Despite the fact that the aforementioned mechanisms involved dual expression of MAPK ERK , the mechanistic distribution of MAPK JNK has not been previously unraveled. Changes in the phosphorylation state of MAPKs may occur during anoxia, thereby reversible protein phosphorylation could be a critical factor and major mechanism of metabolic reorganization for enduring
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